1-Tosyl-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester - Names and Identifiers
Name | 1-(p-tolylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine
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Synonyms | 1-Tosyl-7-azaindole-3-boronic Acid Pinacol Este 1-Tosyl-7-azaindole-3-boronic Acid Pinacol Ester 1-Tosyl-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester 1-[(4-Methylphenyl)sulfonyl]-7-Azaindole-3-boronic acid pinacol ester 3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine 1-[(4-Methylbenzene)sulfonyl]-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester 1-(p-tolylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine 1-[(4-Methylbenzene)sulfonyl]-3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
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CAS | 866545-91-7
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InChI | InChI=1/C20H23BN2O4S/c1-14-8-10-15(11-9-14)28(24,25)23-13-17(16-7-6-12-22-18(16)23)21-26-19(2,3)20(4,5)27-21/h6-13H,1-5H3 |
1-Tosyl-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester - Physico-chemical Properties
Molecular Formula | C20H23BN2O4S
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Molar Mass | 398.28 |
Density | 1.24 |
Boling Point | 572.0±60.0 °C(Predicted) |
Flash Point | 299.8°C |
Vapor Presure | 4.28E-13mmHg at 25°C |
pKa | 0.91±0.30(Predicted) |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
Refractive Index | 1.595 |
1-Tosyl-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester - Introduction
1-(p-tolylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine (abbreviated as TPP-Bpin) is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
- TPP-Bpin is a white crystalline solid.
-It is stable at room temperature.
-Its molecular formula is C22H25BNO4S and its molecular weight is 403.42g/mol.
- TPP-Bpin is an organic borate ester compound.
Use:
- TPP-Bpin are commonly used in organic synthesis as reagents and intermediates.
-It can participate in palladium-catalyzed coupling reactions, such as Suzuki reaction and Heck reaction.
- TPP-Bpin can also be used as a basic reagent for constructing aromatic rings and pyrrolo [2,3-b] pyridine skeletons.
Preparation Method:
-Generally, the method of preparing TPP-Bpin is to first synthesize 1-p-toluenesulfonyl-1H-pyrrolo [2,3-b] pyridine-3-hydroxy acid (TPP-OH for short).
-TPP-Bpin can be obtained by reacting TPP-OH with 4,4, 5,5-tetramethyl -1,3, 2-dioxazole borate.
Safety Information:
-The safety of TPP-Bpin has not been systematically studied, so care should be taken when handling and storing.
-It may cause irritation to the skin, eyes and inhalation.
-Before use, appropriate personal protective measures should be taken, such as wearing gloves and goggles, and providing good ventilation.
Please note that the use of chemicals should comply with local laws and regulations and only be carried out under suitable laboratory conditions.
Last Update:2024-04-10 22:29:15